About Us
PainUSA is a Stanford-led digital health initiative designed to bring patients, clinicians, and researchers together around better chronic pain care. Under the leadership of Dr. Sean Mackey and Dr. Beth Darnall, the platform prioritizes scalable education, registry-informed insights, and sustained community engagement.

Mission & Vision
PainUSA’s mission is to improve the lives of people with pain by building a national, patient-centered learning health system that generates real-world evidence, accelerates discovery, and drives better, more equitable pain care.
We envision future in which pain care is guided by high-quality real-world data, informed by patients’ lived experiences, and translated rapidly into effective, accessible, and accountable care for all.
We envision future in which pain care is guided by high-quality real-world data, informed by patients’ lived experiences, and translated rapidly into effective, accessible, and accountable care for all.
Chronic pain affects over 100 million Americans, with an economic impact of $560-635 billion annually.
PainUSA provides enhanced education for patients, the public, and healthcare professionals to improve understanding and management of pain.
By using real-world data, personalized recommendations are delivered at point of care for every patient.
Our Board

Sean Mackey, MD, PhD
Board Member, PainUSA
Sean Mackey is a physician-scientist and pain medicine specialist at Stanford University, where he is the Division Chief for Pain Medicine. His work focuses on learning health systems, neurosciences of human pain conditions, real-world data, and scalable, evidence-based treatments for chronic pain. He has led numerous NIH-funded studies and national initiatives aimed at improving pain outcomes while reducing harm and inequity in care.

Beth Darnall, PhD
Co-founder, PainUSA
Beth Darnall is a clinical health psychologist and internationally recognized leader in evidence-based behavioral pain treatment. At Stanford University, she has pioneered scalable pain psychology interventions, including Empowered Relief, with a focus on accessibility, rigor, and real-world impact. Her work bridges science, clinical care, and public health to improve outcomes for people living with pain.